- 专利标题: ANIMAL MODEL OF NEURONAL INJURY
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申请号: US15614597申请日: 2017-06-05
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公开(公告)号: US20170266322A1公开(公告)日: 2017-09-21
- 发明人: Katerina Akassoglou , Jae Kyu Ryu
- 申请人: The J. David Gladstone Institutes, a testamentary established under the Will of J. David Glads
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A01K67/027 ; C07K14/75
摘要:
The present invention provides non-human animal models of neuronal injury and/or cognitive dysfunction and methods of making and using such animal models. The animal models of the invention are particularly suited to assessing neurodegeneration in selected regions of interest in the CNS, and thus especially useful for testing the therapeutic efficacy of agents targeting neurodegeneration associated with aging, neurodegenerative diseases, autoimmunity and trauma (e.g., ischemia).