发明申请
- 专利标题： Protein A Binding Polypeptides, Anti-EphA2 Antibodies and Methods of Use Thereof
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申请号： US15457857申请日： 2017-03-13
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公开(公告)号： US20170267768A1公开(公告)日： 2017-09-21
- 发明人: James D. Marks , Daryl Drummond , Melissa Geddie , Dmitri Kirpotin , Neeraj Kohli , Alexey Lugovskoy
- 申请人： The Regents of the University of California , Merrimack Pharmaceuticals, Inc.
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/12
摘要：
Provided by the present disclosure are antibodies (e.g., scFvs) that include CDRs and human framework regions that confer useful properties upon the antibodies. In certain embodiments, such properties include thermostability (e.g., increased melting temperature), efficient binding to Staphylococcus aureus Protein A, or both. In certain aspects, the antibodies are internalizing antibodies that specifically bind to the tumor associated antigen EphA2.
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