- 专利标题: PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES
-
申请号: US15635063申请日: 2017-06-27
-
公开(公告)号: US20170290924A1公开(公告)日: 2017-10-12
- 发明人: Scott Jeffrey , Patrick Burke , Philip Wilson Howard
- 申请人: SEATTLE GENETICS, INC. , MEDIMMUNE LIMITED
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; C07K19/00 ; C07D487/16 ; A61K31/5513
摘要:
A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
公开/授权文献
- US10328084B2 Pyrrolobenzodiazepines and targeted conjugates 公开/授权日:2019-06-25
信息查询