An automated truck unloader (10) for unloading/unpacking product, such as boxes or cases, from trailers and containers is disclosed. In one embodiment, a mobile base structure provides a support framework for a drive subassembly, conveyance subassembly, an industrial robot (56), a distance measurement subassembly, and a control subassembly (62). Under the operation of the control subassembly, an industrial robot (56) having a suction cup-based gripper arm selectively removes boxes from the trailer and places the boxes on a powered transportation path (88). The control subassembly (62) coordinates the selective articulated movement of the industrial robot (56) and the activation of the drive subassembly based upon a perception-based robotic manipulation system.