Invention Application
- Patent Title: SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES
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Application No.: US15599337Application Date: 2017-05-18
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Publication No.: US20170327497A1Publication Date: 2017-11-16
- Inventor: Mark E. Adams , Rongliang Chen , Betty Lam , Matthew Lardy , Srinivasa Reddy Natala , Steven James Wilkens , Mitsunori Kono , Zhe Nie
- Applicant: Takeda Pharmaceutical Company Limited
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D498/04 ; C07D495/04 ; C07D487/04 ; A61K31/5383 ; A61K31/5365 ; A61K31/519 ; A61K31/4985 ; A61K31/437 ; C07D519/00 ; A61K31/4365

Abstract:
Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, p, R1, R2, R3a, R4, and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, cancer, and other disorders, diseases, and conditions for which inhibition of SYK is indicated.
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