A handheld dispensing device has a first dispensing element configured to dispense a structural material and a second dispensing element configured to dispense a biological material. The second dispensing element is single-use and sterilizable. The first dispensing element is connectable to the second dispensing element. A dispensing system also is provided and has a sterilizable chamber; at least one robotic arm assembly and a dispensing device within the sterilizable chamber. The at least one robotic assembly is configured to move the dispensing device that has a first dispensing element and a second dispensing element. The first dispensing element is releasably connectable to the second dispensing element. An external control is device connected to the robotic arm assembly and controls the at least one robotic arm assembly. The first dispensing element dispenses a structural material and the second dispensing element dispenses a biological material.