The subject matter described herein includes methods, systems, and computer readable medium for scrambled communication of data to, from, or over a medium. According to one aspect, the subject matter described herein includes a method for communicating data in scrambled form to or over a medium. The method includes receiving analog or digital data to be transmitted to or over a medium. The method further includes modulating samples representing at least signal using the analog or digital data to produce data modulated signal samples. The method further includes scrambling the data modulated signal samples using a predetermined scrambling algorithm. The method further includes transmitting the scrambled data modulated signal samples to or over the medium. The method further includes descrambling samples received from the medium using the inverse of the predetermined scrambling algorithm to obtain the unscrambled modulated signal samples, which can then be demodulated to retrieve original data.