发明申请
- 专利标题: NEPRILYSIN INHIBITORS
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申请号: US15581327申请日: 2017-04-28
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公开(公告)号: US20170355664A1公开(公告)日: 2017-12-14
- 发明人: Melissa Fleury , Adam D. Hughes
- 申请人: THERAVANCE BIOPHARMA R&D IP, LLC
- 申请人地址: US CA South San Francisco
- 专利权人: THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人: THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人地址: US CA South San Francisco
- 主分类号: C07C229/22
- IPC分类号: C07C229/22 ; A61K31/4439 ; C07D401/04 ; C07D405/14 ; C07C271/22 ; C07D249/12 ; C07D231/20 ; C07D261/18 ; A61K31/4192 ; A61K31/415 ; C07D257/04 ; A61K31/42 ; C07D207/26 ; A61K31/675 ; A61K31/41 ; A61K31/4155 ; A61K45/06 ; C07D249/18 ; C07F9/6503 ; C07D249/04 ; C07D263/38 ; A61K31/4196 ; C07D253/08 ; C07D231/18 ; C07D405/12 ; C07D231/14
摘要:
In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
公开/授权文献
- US09884807B2 Neprilysin inhibitors 公开/授权日:2018-02-06
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