- 专利标题： mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS
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申请号： US15546630申请日： 2016-01-25
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公开(公告)号： US20180002435A1公开(公告)日： 2018-01-04
- 发明人: Barbara Johnson SASU , Arvind RAJPAL , Philippe DUCHATEAU , Alexandre JUILLERAT , Julien VALTON
- 申请人： Cellectis , RINAT NEUROSCIENCE CORPORATION
- 优先权： DKPA201570044 20150126
- 国际申请： PCT/EP2016/051467 WO 20160125
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K14/705 ; G01N15/10 ; G01N15/14 ; C12N5/0783 ; C07K14/725 ; G01N15/00
摘要：
A polypeptide encoding a chimeric antigen receptor (CAR) comprising at least one extracellular binding domain that comprises a scFv formed by at least a VH chain and a VL chain specific to an antigen, wherein said extracellular binding domain comprises at least one mAb-specific epitope.
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