Invention Application
- Patent Title: METHOD FOR MEASURING REACTIVITY OF FVIII
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Application No.: US15512187Application Date: 2015-09-24
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Publication No.: US20180011114A1Publication Date: 2018-01-11
- Inventor: Keiji Nogami , Midori Shima , Tetsuhiro Soeda , Takehisa Kitazawa
- Applicant: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY , CHUGAI SEIYAKU KABUSHIKI KAISHA
- Applicant Address: JP Nara JP Tokyo
- Assignee: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY,CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY,CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee Address: JP Nara JP Tokyo
- Priority: JP2014-196974 20140926
- International Application: PCT/JP2015/076848 WO 20150924
- Main IPC: G01N33/86
- IPC: G01N33/86 ; C07K16/36
Abstract:
The inventors produced substances that neutralize the activity of a bispecific antibody having an activity of functionally substituting for FVIII, and undertook the construction of methods for measuring the reactivity of FVIII that can ensure accuracy even in the presence of this bispecific antibody. As a result, the inventors discovered that in APTT-based one-stage clotting assay, FVIII activity in the plasma of a hemophilia A patient can be evaluated accurately, and also that in APTT-based Bethesda assay, FVIII inhibitor titer in the plasma of a hemophilia A patient carrying a FVIII inhibitor can be evaluated accurately.
Public/Granted literature
- US11150254B2 Method for measuring reactivity of FVIII Public/Granted day:2021-10-19
Information query
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