发明申请
- 专利标题： NOVEL ANTI-PAD4 ANTIBODY
-
申请号： US15555808申请日： 2016-03-07
-
公开(公告)号： US20180044434A1公开(公告)日： 2018-02-15
- 发明人: Mamoru SATO , Michiyuki YAMADA , Satoshi KANAZAWA , Masayoshi TOYOURA , Yuji SHOYA , Kenji SAITO , Chihiro YAMAZAKI
- 申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY , PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY , PHARMA FOODS INTERNATIONAL CO., LTD.
- 优先权： JP2015-044518 20150306
- 国际申请： PCT/JP2016/057030 WO 20160307
- 主分类号： C07K16/40
- IPC分类号： C07K16/40
摘要：
Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0×10−9 or less. Optionally, the anti-PAD4 antibody and a TNFα inhibitor are used in combination.
公开/授权文献
- US11447569B2 Anti-PAD4 antibody 公开/授权日：2022-09-20