There are disclosed a display substrate and a display device. The display substrate comprises a common electrode line, a plurality of pixel units with each comprising a pixel electrode and a plurality of first switch units disposed respectively between the common electrode line and the pixel electrodes. Each of the first switch unit is configured to be turned on within a pre-set time period after the display substrate is powered off to connect the pixel electrode to the common electrode line and be turned off when the display substrate is powered on to disconnect the pixel electrode from the common electrode line. In this way, after the power-off, the charges stored in the pixel electrode are neutralized in the common electrode line. Thus, the pixel electrode and the common electrode can be discharged by the same discharge circuit, which guarantees no DC residue in the discharged pixel electrode.