Invention Application
- Patent Title: BICYCLIC KETONE SULFONAMIDE COMPOUNDS
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Application No.: US15554801Application Date: 2016-03-02
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Publication No.: US20180051021A1Publication Date: 2018-02-22
- Inventor: Matthew WEISS , Benjamin Charles MILGRAM , Thomas DINEEN , John STELLWAGEN , Angel GUZMAN-PEREZ , Alessandro BOEZIO , Issac E. MARX
- Applicant: AMGEN INC.
- Applicant Address: US CA THOUSAND OAKS
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA THOUSAND OAKS
- International Application: PCT/US2016/020403 WO 20160302
- Main IPC: C07D471/04
- IPC: C07D471/04

Abstract:
The present invention provides compounds of Formula (I), wherein: as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
Public/Granted literature
- US10472356B2 Bicyclic ketone sulfonamide compounds Public/Granted day:2019-11-12
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