发明申请
- 专利标题： Use of Excess Carbodiimide for Peptide Synthesis at Elevated Temperatures
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申请号： US15686719申请日： 2017-08-25
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公开(公告)号： US20180066013A1公开(公告)日： 2018-03-08
- 发明人: Jonathan M. Collins , Sandeep K. Singh
- 申请人： CEM Corporation
- 申请人地址： US NC Matthews
- 专利权人： CEM Corporation
- 当前专利权人： CEM Corporation
- 当前专利权人地址： US NC Matthews
- 主分类号： C07K1/107
- IPC分类号： C07K1/107 ; C07K1/08 ; C07K1/06 ; C07K1/04 ; C07C267/00
摘要：
An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same vessel, in the presence of a carbodiimide in an amount greater than 1 equivalent as compared to the amino acid, in the presence of an activator additive, and at a temperature greater than 30° C.
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