Techniques are described for automated analysis and filtering of image data. Image data is analyzed to identify regions of interest (ROIs) within the image content. The image data also may have depth estimates applied to content therein. One or more of the ROIs may be designated to possess a base depth, representing a depth of image content against which depths of other content may be compared. Moreover, the depth of the image content within a spatial area of an ROI may be set to be a consistent value, regardless of depth estimates that may have been assigned from other sources. Thereafter, other elements of image content may be assigned content adjustment values in gradients based on their relative depth in image content as compared to the base depth and, optionally, based on their spatial distance from the designated ROI. Image content may be adjusted based on the content adjustment values.