Invention Application
- Patent Title: PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF
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Application No.: US15691017Application Date: 2017-08-30
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Publication No.: US20180072785A1Publication Date: 2018-03-15
- Inventor: KATSUTO TAMAI , TAKEHIKO YAMAZAKI , TSUTOMU KANEZAKI , SHIGERU SAKURAI , YUKIKO NOGUCHI , MAYUMI ENDO , NATSUMI HAMABUCHI , KANA NAITO
- Applicant: GENOMIX CO., LTD. , OSAKA UNIVERSITY
- Priority: JP2011-098270 20110426; JP2011-219454 20111003
- Main IPC: C07K14/47
- IPC: C07K14/47

Abstract:
(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.
Public/Granted literature
- US10550165B2 Peptide for inducing regeneration of tissue and use thereof Public/Granted day:2020-02-04
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