A reconfigurable fastener multi-spindle tool system includes multiple spindle assemblies, each including a support ring and a support arm sleeve received in the support ring and rotatable on a central longitudinal axis of the support ring. At least one support arm is connected to the support ring. The at least one support arm rotates with respect to the central longitudinal axis. A spindle is fixed to the support arm and is displaceable with respect to the central longitudinal axis. The spindle has an adaptor to temporarily retain and torque a fastener. A reaction plate is connected to the spindle and has a geometric shape. At least one template plate has multiple openings each having a geometric shape matching the geometric shape of the reaction plate. One of the openings receives the reaction plate thereby preventing axial rotation of the spindle.