A method of making a web of multi-dose cleaning products may include forming first and second pluralities of internal holders in a first film, forming a first plurality of external holders in an carrier sheet corresponding with the first plurality of internal holders, and forming a second plurality of external holders in the carrier sheet corresponding with the second plurality of internal holders. The method may also include filling each of the first plurality of internal holders with a first cleaning composition, and filling each of the second plurality of internal holders with a second cleaning composition. Furthermore, the method may include sealing a second film to the first film to define first and second pluralities of pouches, folding the carrier sheet so that each of the first plurality of pouches overlaps a corresponding one of the second plurality of pouches, and sealing together overlapping portions of the carrier sheet.