- 专利标题： VACCINE COMPOSITIONS HAVING IMPROVED STABILITY AND IMMUNOGENICITY
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申请号： US15819962申请日： 2017-11-21
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公开(公告)号： US20180133308A1公开(公告)日： 2018-05-17
- 发明人: Gale SMITH , Ye LIU , Jing-Hui TIAN , Michael J. MASSARE , Sarathi BODDAPATI , Erica SHANE , Cynthia OLIVER , Gregory GLENN
- 申请人： Novavax, Inc.
- 申请人地址： US MD Gaithersburg
- 专利权人： Novavax, Inc.
- 当前专利权人： Novavax, Inc.
- 当前专利权人地址： US MD Gaithersburg
- 主分类号： A61K39/155
- IPC分类号： A61K39/155 ; A61K9/16 ; C12N7/00 ; A61K9/00 ; A61K39/00
摘要：
Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
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