- 专利标题: RETROVIRAL PARTICLE COMPRISING AT LEAST TWO ENCAPSIDATED NONVIRAL RNAS
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申请号: US15574337申请日: 2016-05-13
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公开(公告)号: US20180135025A1公开(公告)日: 2018-05-17
- 发明人: Pascale BOUILLE , Jean-Christophe PAGES , Régis GAYON
- 申请人: VECTALYS
- 优先权: FR1554381 20150515; FR1653280 20160413
- 国际申请: PCT/FR2016/051152 WO 20160513
- 主分类号: C12N7/00
- IPC分类号: C12N7/00 ; A61K48/00
摘要:
The present invention relates to a retroviral system for the transfer of non-viral RNA into target cells and more particularly a retroviral particle capable of delivering multiple RNAs. More particularly, it relates to retroviral particles comprising a protein derived from the Gag polyprotein an envelope protein, optionally an integrase and at least two encapsidated non-viral RNAs, the encapsidated non-viral RNAs each comprising an RNA sequence of interest linked to an encapsidation sequence, each encapsidation sequence being recognised by a binding domain introduced into the protein derived from the Gag polyprotein and/or into the integrase.
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