• 专利标题: RETROVIRAL PARTICLE COMPRISING AT LEAST TWO ENCAPSIDATED NONVIRAL RNAS
  • 申请号: US15574337
    申请日: 2016-05-13
  • 公开(公告)号: US20180135025A1
    公开(公告)日: 2018-05-17
  • 发明人: Pascale BOUILLEJean-Christophe PAGESRégis GAYON
  • 申请人: VECTALYS
  • 优先权: FR1554381 20150515; FR1653280 20160413
  • 国际申请: PCT/FR2016/051152 WO 20160513
  • 主分类号: C12N7/00
  • IPC分类号: C12N7/00 A61K48/00
RETROVIRAL PARTICLE COMPRISING AT LEAST TWO ENCAPSIDATED NONVIRAL RNAS
摘要:
The present invention relates to a retroviral system for the transfer of non-viral RNA into target cells and more particularly a retroviral particle capable of delivering multiple RNAs. More particularly, it relates to retroviral particles comprising a protein derived from the Gag polyprotein an envelope protein, optionally an integrase and at least two encapsidated non-viral RNAs, the encapsidated non-viral RNAs each comprising an RNA sequence of interest linked to an encapsidation sequence, each encapsidation sequence being recognised by a binding domain introduced into the protein derived from the Gag polyprotein and/or into the integrase.
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