- 专利标题： PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS
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申请号： US15868593申请日： 2018-01-11
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公开(公告)号： US20180135121A1公开(公告)日： 2018-05-17
- 发明人: Jingyue Ju , Zengmin Li , Sergey Kalachikov , Carl Fuller
- 申请人： Jingyue Ju , Zengmin Li , Sergey Kalachikov , Carl Fuller
- 申请人地址： US NY New York City
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US NY New York City
- 主分类号： C12Q1/6874
- IPC分类号： C12Q1/6874 ; C12N9/96 ; C12N9/12 ; C07K14/31
摘要：
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming conjugates in nanopore devices and methods.