A frame sealing glue includes a frame sealing glue body having an inner layer portion (211) and an outer layer portion (212). The frame sealing glue further includes an intermediate film layer (22) disposed between the inner layer portion (211) and the outer layer portion (212), and a plurality of enclosed spaces (P) are formed by the intermediate film layer (22) and the inner layer portion (211) or the outer layer portion (212) of the frame sealing glue body. A display panel and a display device are also provided. By means of the frame sealing glue, the display panel and the display device according to the embodiments of the present disclosure, it avoids a leakage phenomenon when the frame sealing glue is broken at different points, thereby increasing ability of the frame sealing glue for resisting external atmospheric pressure.