- 专利标题： NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE
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申请号： US15866632申请日： 2018-01-10
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公开(公告)号： US20180139941A1公开(公告)日： 2018-05-24
- 发明人: Andrew J. Murphy , O. Gavin Thurston , Bindu Varghese , Cagan Gurer
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C12N15/89 ; A61K49/00 ; G01N33/50 ; C07K14/705 ; C12N15/85 ; C07K16/28 ; C12N15/90 ; C12N9/16
摘要：
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.
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