发明申请
- 专利标题: COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
-
申请号: US15885783申请日: 2018-01-31
-
公开(公告)号: US20180169267A1公开(公告)日: 2018-06-21
- 发明人: Mariola FOTIN-MLECZEK , Patrick BAUMHOF
- 申请人: CureVac AG
- 申请人地址: DE Tübingen
- 专利权人: CureVac AG
- 当前专利权人: CureVac AG
- 当前专利权人地址: DE Tübingen
- 优先权: EPPCT/EP2007/007702 20070904
- 主分类号: A61K48/00
- IPC分类号: A61K48/00 ; C12N15/87 ; C12N9/02 ; C07K19/00 ; A61K47/64 ; A61K39/00 ; A61K38/45
摘要:
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the function of cell-penetrating peptide (CPP), has a length of 8 to 15 amino acids and has the empirical formula (Arg)l;(Lys)m;(His)n;(Om)o;(Xaa)x with the majority of residues being selected from Arg, Lys, His, Om. The invention further relates to a method for transfecting a cell or an organism, thereby applying the inventive complexed RNA. Additionally, pharmaceutical compositions and kits comprising the inventive complexed RNA, as well as the use of the inventive complexed RNA for transfecting a cell, tissue or an organism and/or for modulating, preferably inducing or enhancing, an immune response are disclosed herein.