- 专利标题： ARMED REPLICATION-COMPETENT ONCOLYTIC ADENOVIRUSES
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申请号： US15847612申请日： 2017-12-19
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公开(公告)号： US20180169271A1公开(公告)日： 2018-06-21
- 发明人: Mark J. Cantwell , Winnie M. Chan , Brett Ewald , Joan M. Robbins
- 申请人： Memgen, LLC , DNAtrix
- 申请人地址： US TX Houston US TX Houston
- 专利权人： Memgen, LLC,DNAtrix
- 当前专利权人： Memgen, LLC,DNAtrix
- 当前专利权人地址： US TX Houston US TX Houston
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07K14/705 ; C12N15/86 ; A61K38/17 ; A61K45/06
摘要：
Disclosed are replication-competent oncolytic adenoviruses, comprising chimeric human/mouse CD40 ligands. The oncolytic adenoviruses may be replication competent. The chimeric human/mouse CD40 ligand may be MEM40. Also disclosed are methods comprising administering a replication competent oncolytic adenovirus armed with at least one chimeric human/mouse CD40 ligand, for example MEM40, to a patient suffering from a cancer.
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