- 专利标题: NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
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申请号: US15314565申请日: 2015-05-29
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公开(公告)号: US20180179247A1公开(公告)日: 2018-06-28
- 发明人: Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis
- 申请人: Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis , SAGE THERAPEUTICS, INC.
- 优先权: CNPCT/CN2014/078820 20140529
- 国际申请: PCT/CN15/80216 WO 20150529
- 主分类号: C07J43/00
- IPC分类号: C07J43/00 ; C07J7/00 ; A61P25/24 ; A61P25/14 ; A61P25/18 ; A61P25/20 ; A61P25/08
摘要:
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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