Disposable cleaning wipes having a use indicator are provided that are suitable for use in home and industrial cleaning applications. The cleaning wipes comprise cellulosic fibers, an antimicrobial agent and an indicator complex, the indicator complex including (i) a colored compound selected from the group consisting of a phthalocyanine compound, an ultramarine compound, and an iron oxide compound, and (ii) a cationic agent. The indicator complex is releasably attached, by ionic bonding, to a discrete region of the fibrous sheet. The anti-microbial compound is also attached, by ionic bonding, to the fibrous sheet. Thus, in use, the indicator complex is released by the fibrous sheet commensurate with the release of antimicrobial agent. The release and loss of the indicator complex provides the user with an indication of when the antimicrobial agent within the fibrous sheet is substantially depleted and the cleaning wipe should be replaced.