- 专利标题： COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
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申请号： US15736925申请日： 2016-06-15
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公开(公告)号： US20180186770A1公开(公告)日： 2018-07-05
- 发明人: Zhuoliang Chen , Jorge Garcia Fortanet , Andriana Jouk , Rajesh Karki , Matthew J. LaMarche , Gang Liu , Mark G. Palermo , Lawrence Blas Perez , Patrick James Sarver , Michael David Shultz , Martin Sendzik , Bakary-Barry Toure , Bing Yu
- 申请人： Zhuoliang Chen , Jorge Garcia Fortanet , Andriana Jouk , Rajesh Karki , Matthew J. LaMarche , Gang Liu , Mark G. Palermo , Lawrence Blas Perez , Patrick James Sarver , Michael David Shultz , Martin Sendzik , Bakary-Barry Toure , Bing Yu
- 国际申请： PCT/IB2016/053550 WO 20160615
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D491/107 ; C07D498/10 ; C07D471/10 ; C07D401/04
摘要：
The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2, R4a, R5b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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