Described herein are systems and methods of dynamically using predictive analytics in control of a hydrocarbon refining process. In one aspect, the method comprises analyzing a hydrocarbon sample, wherein the hydrocarbon sample is representative of an amount of hydrocarbon entering a refining process; developing one or more predictive models of the hydrocarbon refining process for the hydrocarbon entering the refining process based on the analysis of the hydrocarbon sample; and dynamically controlling aspects of the hydrocarbon refining process as the hydrocarbon entering the refining process moves through the refining process based on the one or more predictive models.