Invention Application
- Patent Title: METHODS FOR MAKING PHARMACEUTICAL SOLID DOSAGE FORMS OF SPRAY-DRIED DISPERSIONS
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Application No.: US15749934Application Date: 2016-07-29
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Publication No.: US20180221282A1Publication Date: 2018-08-09
- Inventor: Yung-Chi Lee , David Harris , Justin David Moser , Michael McNevin , Amber Broadbent , Robert Hall , Ari Ericson
- Applicant: Yung-Chi LEE , David HARRIS , Justin David MOSER , Michael MCNEVIN , Amber BROADBENT , Robert HALL , Ari ERICSON , Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US16/44604 WO 20160729
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K9/10 ; A61K31/5365 ; A61K9/20

Abstract:
A process for drying a spray dried dispersion, comprising: a) providing a spray-dried dispersion comprising particles wherein the particles comprise an active agent and a polymer and optionally one or more surfactants, the dispersion having an average particle diameter of less than about 100 m; b) blending an amount of silicon dioxide with the dispersion to form a dispersion-silicon dioxide blend, wherein the amount of silicon dioxide relative to the amount of dispersion is between about 0.5 and 2.0% by weight; c) drying the blend with a secondary dryer.
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