发明申请
- 专利标题： METHODS FOR MAKING PHARMACEUTICAL SOLID DOSAGE FORMS OF SPRAY-DRIED DISPERSIONS
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申请号： US15749934申请日： 2016-07-29
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公开(公告)号： US20180221282A1公开(公告)日： 2018-08-09
- 发明人: Yung-Chi Lee , David Harris , Justin David Moser , Michael McNevin , Amber Broadbent , Robert Hall , Ari Ericson
- 申请人： Yung-Chi LEE , David HARRIS , Justin David MOSER , Michael MCNEVIN , Amber BROADBENT , Robert HALL , Ari ERICSON , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US16/44604 WO 20160729
- 主分类号： A61K9/16
- IPC分类号： A61K9/16 ; A61K9/10 ; A61K31/5365 ; A61K9/20
摘要：
A process for drying a spray dried dispersion, comprising: a) providing a spray-dried dispersion comprising particles wherein the particles comprise an active agent and a polymer and optionally one or more surfactants, the dispersion having an average particle diameter of less than about 100 m; b) blending an amount of silicon dioxide with the dispersion to form a dispersion-silicon dioxide blend, wherein the amount of silicon dioxide relative to the amount of dispersion is between about 0.5 and 2.0% by weight; c) drying the blend with a secondary dryer.
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