Invention Application
- Patent Title: CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA
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Application No.: US15749611Application Date: 2016-08-02
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Publication No.: US20180221344A1Publication Date: 2018-08-09
- Inventor: Hai-Yun Xiao , T.G. Murali Dhar , Bin Jiang , Jingwu Duan
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- International Application: PCT/US2016/045104 WO 20160802
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; A61K31/4188 ; A61P37/02

Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: Ring A is 3- to 6-membered carbocyclic or heterocyclic ring; X is CR1 or N; Y is —(CR5R5)m—; Z is —(CR5R5)n—; and q, R1, R2, R3, R4, R6, R7, R8, R9, and R10 are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Public/Granted literature
- US10335392B2 Cyclic compounds useful as modulators of TNF α Public/Granted day:2019-07-02
Information query
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