- 专利标题: ANTIMICROBIAL CATIONIC POLYCARBONATES
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申请号: US15954776申请日: 2018-04-17
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公开(公告)号: US20180228835A1公开(公告)日: 2018-08-16
- 发明人: Willy Chin , Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Ashlynn L. Z. Lee , Victor W. L. Ng , Zhan-Yuin Ong , Yi Yan Yang
- 申请人: International Business Machines Corporation , Agency For Science, Technology and Research
- 主分类号: A61K31/785
- IPC分类号: A61K31/785 ; C08G64/02 ; A01N25/10 ; A01N33/12 ; A61K31/80
摘要:
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
公开/授权文献
- US10786530B2 Antimicrobial cationic polycarbonates 公开/授权日:2020-09-29
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