- 专利标题: OLIGOMER-CORTICOSTEROID CONJUGATES
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申请号: US15788626申请日: 2017-10-19
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公开(公告)号: US20180256599A1公开(公告)日: 2018-09-13
- 发明人: Wen Zhang , Jennifer Riggs-Sauthier , J. Milton Harris , Michael D. Bentley
- 申请人: Nektar Therapeutics
- 主分类号: A61K31/573
- IPC分类号: A61K31/573 ; C07J41/00
摘要:
The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.
公开/授权文献
- US11464788B2 Oligomer-corticosteroid conjugates 公开/授权日:2022-10-11