DEVICES AND METHODS FOR TREATING HEART FAILURE
摘要:
The present teachings provide a device to change the pressure in a chamber of a heart and methods of making and using thereof. One aspect of the present teachings provides a device comprising a frame (for example, a metallic frame) and a scaffold. The frame of the device has a distal flange portion, a shunt portion, and a proximal flange portion. The distal and proximal flange portions can align with the shunt portion and form an elongated first profile. At least one of the distal and proximal flange portions can bend radially away from the shunt portion to form a flange like profile. The scaffold includes one or more than covering layers and encloses parts of the frame or the entire frame. The covering layer provides a barrier between the biological matter and the frame of the device. The scaffold is designed to control and direct tissue growth, for example, by stimulating an irritation response and inducing cell proliferation around the retention flange and/or discouraging cell proliferation inside the shunt portion.
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