A solid-state switch architecture for multi-mode operation of a thermoelectric device and a method of operating such a device are provided herein. The switch architecture includes one or more inputs operable to receive power from one or more power supplies. The switch architecture also includes multiple outputs operable to provide power to respective channels of the thermoelectric device. The switch architecture also includes multiple solid-state switches operable to connect the one or more inputs to the outputs and a controller operable to toggle the solid-state switches to provide multiple modes of operation of the thermoelectric device. In this way, the thermoelectric device can be operated in a more efficient way while decreasing the size and increasing the reliability of the switch architecture. Also, this may allow the use of standard and less expensive power supplies. This may result in a significant reduction in cost and an increase in reliability.