发明申请
- 专利标题： EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE
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申请号： US15758505申请日： 2016-09-09
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公开(公告)号： US20180280497A1公开(公告)日： 2018-10-04
- 发明人: Robert SEDER , Geoffrey LYNN , Leonard SEYMOUR
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , The Chancellor, Masters and Scholars of the University of Oxford
- 申请人地址： GB Oxford
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Serv,The Chancellor, Masters and Scholars of the University of Oxford
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Serv,The Chancellor, Masters and Scholars of the University of Oxford
- 当前专利权人地址： GB Oxford
- 国际申请： PCT/US2016/051037 WO 20160909
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; A61K47/64 ; A61K48/00 ; A61K47/59 ; A61K47/65
摘要：
Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.