发明申请
- 专利标题： ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TWO OR MORE ANTIGEN MOLECULES REPEATEDLY
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申请号： US15952951申请日： 2018-04-13
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公开(公告)号： US20180282719A1公开(公告)日： 2018-10-04
- 发明人: Tomoyuki IGAWA , Shinya Ishii , Atsuhiko Maeda , Takashi Nakai
- 申请人： Chugai Seiyaku Kabushiki Kaisha
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 优先权： JP2008-104147 20080411; JP2008-247713 20080926; JP2009-068744 20090319
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; G01N33/68 ; A61K39/145 ; C07K16/24 ; C07K16/28 ; A61K39/12 ; A61K39/00
摘要：
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
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