- 专利标题： ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS
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申请号： US15943527申请日： 2018-04-02
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公开(公告)号： US20180296693A1公开(公告)日： 2018-10-18
- 发明人: Daulet SATPAYEV , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Jean GUDAS , Aya JAKOBOVITS , Michael TORGOV , Zili AN
- 申请人： AGENSYS, INC. , SEATTLE GENETICS, INC.
- 主分类号： A61K47/68
- IPC分类号： A61K47/68
摘要：
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.