Tissue fixation systems, delivery tools, kits that include a tissue fixation system, and methods of treatment that use a tissue fixation system are described herein. An example embodiment of a tissue fixation system includes an anchor, a set screw, and a tissue manipulator. The anchor has a shaft and a head attached to the shaft. The set screw is partially disposed within a passageway defined by the anchor and is moveable between a first position and a second position. The tissue manipulator is partially disposed within the passageway defined by the anchor and is removable from the anchor when the set screw is in the first position and is releasably attached to the anchor when the set screw is in the second position.