An omnidirectional scientific toothbrush includes a brush handle and a brush head having a U-shaped structure. A central gearset, and tooth outer side brush rollers and tooth inner side brush rollers, both of which are respectively arranged in an upper row and a lower row according to tooth layout, and a tooth end surface brush roller driven by the central gearset are installed in an inner cavity of the brush head. The tooth end surface brush roller is located in a space defined by the tooth outer side brush rollers and the tooth inner side brush rollers. The rotating action of the tooth end surface brush roller allows the tooth end surface brush roller to simultaneously brush occlusal surfaces of Upper and lower rows of teeth. Thus the cleaning operation of all of the teeth in the mouth may just be finished at one time automatically.