Invention Application
- Patent Title: USE OF COMPLEMENT PATHWAY INHIBITORS TO TREAT OCULAR DISEASES
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Application No.: US15844391Application Date: 2017-12-15
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Publication No.: US20180334495A1Publication Date: 2018-11-22
- Inventor: Sek Chung FUNG , Zhengbin YAO
- Applicant: GENENTECH, INC.
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C12N15/113 ; A61K45/06 ; A61K38/17 ; A61K39/395 ; A61K38/00 ; A61K39/00

Abstract:
The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic M retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.
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