An optical fiber design method according to the present invention is a design method of a photonic crystal fiber having a plurality of holes arranged in the optical fiber along a longitudinal direction, in which a required effective cross-sectional area is calculated from a light wavelength, a transmission distance, and output power such that, in a cross section, a hole ratio which is an area of the holes per unit area is larger in a central side than in an outer side in a portion corresponding to a cladding, and a fiber structure (hole diameter and hole interval) corresponding to the effective cross-sectional area is calculated.