- 专利标题： MODIFIED THERAPEUTIC AGENTS, STAPLED PEPTIDE LIPID CONJUGATES, AND COMPOSITIONS THEREOF
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申请号： US16000829申请日： 2018-06-05
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公开(公告)号： US20180344812A1公开(公告)日： 2018-12-06
- 发明人: Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
- 申请人： THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH , THE SCRIPPS RESEARCH INSTITUTE
- 主分类号： A61K38/22
- IPC分类号： A61K38/22 ; A61K45/06 ; A61K38/26 ; A61K9/00 ; A61K47/54 ; A61K47/60 ; A61K9/70
摘要：
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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