- 专利标题: METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH PATHOLOGICAL NEOVASCULARIZATION
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申请号: US15775550申请日: 2016-11-12
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公开(公告)号: US20180355030A1公开(公告)日: 2018-12-13
- 发明人: William GREENE , Kirk DORNBUSH , Thi-Sau MIGONE , Gabriela BURIAN
- 申请人: Iconic Therapeutics, Inc.
- 国际申请: PCT/US16/61723 WO 20161112
- 主分类号: C07K16/22
- IPC分类号: C07K16/22 ; C07K14/745 ; A61K39/395 ; A61K47/64 ; A61P35/00 ; A61P27/02
摘要:
Provided herein are immunoconjugate dimers for the treatment of disorders associated with neovascularization and tumor-associated neovascularization (e.g ocular melanoma) and symptoms associated with the same. The methods comprises administering to the patient in one or more dosing sessions, a composition comprising an effective amount of any one or more of the immunoconjugate dimers of the invention, wherein the monomer subunits of the dimer each comprises a mutated factor VIIa (FVIIa) protein conjugated to a immunoglobulin G1 (IgG1) Fc domain.