- 专利标题： Genetically Engineered Swine Influenza Virus And Uses Thereof
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申请号： US16126791申请日： 2018-09-10
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公开(公告)号： US20180369363A1公开(公告)日： 2018-12-27
- 发明人: Peter Palese , Adolfo Garcia-Sastre , Richard J. Webby , Juergen A. Richt , Robert G. Webster , Kelly M. Lager
- 申请人： Icahn School of Medicine at Mount Sinai , St. Jude Children's Research Hospital , The United States of America, As Represented by the Secretary of Agriculture
- 申请人地址： US NY New York US TN Memphis US WA Washington
- 专利权人： Icahn School of Medicine at Mount Sinai,St. Jude Children's Research Hospital,The United States of America, As Represented by the Secretary of Agriculture
- 当前专利权人： Icahn School of Medicine at Mount Sinai,St. Jude Children's Research Hospital,The United States of America, As Represented by the Secretary of Agriculture
- 当前专利权人地址： US NY New York US TN Memphis US WA Washington
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; C12N7/00 ; A61K39/12 ; A61K39/00
摘要：
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.
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