The disclosure relates to a data line demultiplexer, a display substrate, a display panel, and a display device. The data line demultiplexer includes a switching module, a plurality of switching signal terminals and a plurality of data signal terminals. The switching module is respectively connected to the plurality of switching signal terminals, the plurality of data signal terminals and M columns of pixel units in a display device. The switching module is capable of communicating each of the data signal terminals with at least two columns of sub-pixels under control of the plurality of switching signal terminals, wherein every two columns of sub-pixels that are connected with one data signal terminal are spaced apart by an odd number of columns of sub-pixels that are connected with other data signal terminals.