Provided are a resource configuration method and device. The method includes: assigning frequency-domain resource blocks (RBs) in a system to one or more sub-channels to form a sub-channel configuration in the system, where each of the RBs is included in only one sub-channel; and determining a unique sub-channel index for each sub-channel, and instructing one or more sub-channels, through the sub-channel index, the RBs included in the instructed one or more sub-channels to carry control information and/or data information of a user equipment. The solution solves the problem of large overheads incurred by indicating configured time-domain/frequency-domain resources in a V2V communication system and reduces overheads incurred by indicating configured time-domain/frequency-domain resources.