- 专利标题： BIFUNCTIONAL COMPOUNDS FOR HER3 DEGRADATION AND METHODS OF USE
-
申请号： US16066150申请日： 2016-12-29
-
公开(公告)号： US20190016703A1公开(公告)日： 2019-01-17
- 发明人: Nathanael S. GRAY , James BRADNER , Pasi JANNE , Jaebong JANG , Hwan Geun CHOI , Eunhwa KO , Joong-Heui CHO
- 申请人： Dana-Farber Cancer Institute, Inc. , Daegu-Gyeongbuk Medical Innovation Foundation
- 国际申请： PCT/US16/69351 WO 20161229
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61P35/00 ; A61K47/54 ; A61K47/18 ; A61K47/08
摘要：
The present invention provides bifunctional compounds which act as protein degradation inducing moieties for a HER family protein, such as Her3. The present invention also provides methods for the targeted degradation of a HER family protein through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to the HER family protein which can be utilized in the treatment of disorders modulated by a HER family protein.
信息查询
