Invention Application
- Patent Title: SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK
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Application No.: US16067619Application Date: 2017-01-13
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Publication No.: US20190016735A1Publication Date: 2019-01-17
- Inventor: Leon M. Smith II , Vladimir Ladziata , Indawati De Lucca , Donald J.P. Pinto , Michael J. Orwat , Andrew K. Dilger , Kumar Balashanmuga Pabbisetty , Wu Yang , Scott A. Shaw , Peter W. Glunz , Manoranjan Panda
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- International Application: PCT/US2017/013323 WO 20170113
- Main IPC: C07D513/04
- IPC: C07D513/04 ; A61P9/10 ; A61P15/10

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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