发明申请
- 专利标题： PHOSPONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR RETENTION OF COMPOUNDS
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申请号： US16072347申请日： 2017-01-24
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公开(公告)号： US20190030171A1公开(公告)日： 2019-01-31
- 发明人: Robert M. Garbaccio , Jeffrey C. Kern , James J. Mulhearn , Philip E. Brandish
- 申请人： Robert M. Garbaccio , Jeffrey C. Kern , James J. Mulhearn , Philip E. Brandish , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US17/14644 WO 20170124
- 主分类号： A61K47/54
- IPC分类号： A61K47/54 ; A61K47/68 ; C07F9/38 ; C07F9/40
摘要：
Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.
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